Comparison of DisCoVisc and Hydroxypropylmethylcellulose 2%

Intraindividual Randomized Clinical Comparison of DisCoVisc and Hydroxypropylmethylcellulose 2% in Phacoemulsification

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01387620

Enrollment

Registered

2011-07-04

Start date

2009-06-30

Completion date

2010-12-31

Last updated

2011-07-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corneal Edema, Intraocular Pressure

Keywords

Phacoemulsification, Corneal Edema, Corneal Endothelium, Viscoelastic Substances

Brief summary

This prospective study was performed to compare two ophthalmic viscosurgical devices, DisCoVisc (hyaluronic acid 1.6% - chondroitin sulfate 4.0%) and hydroxypropylmethylcellulose 2% in terms of their overall clinical performance during phacoemulsification.

Interventions

DRUGHyaluronic Acid and hydroxypropylmethylcellulose

Hyaluronic Acid 1.6% was used to performed phacoemulsification in one eye and hydroxypropylmethylcellulose 2% was used in the fellow eye.

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 90 Years

Healthy volunteers

Inclusion criteria

* Bilateral age-related cataract * Grade 1-3 lens opacities classification system (LOCS III) * Pupil dilatation greater than 7.0 mm

Exclusion criteria

* Black, brunescent, traumatic or subluxated cataract * Corneal endothelial disease (endothelial cell count less than 2.000 cells/mm3) * Glaucoma, uveitis * Previous ocular surgery

Design outcomes

Primary

Measure	Time frame
Corneal endothelial cell count	6 months

Secondary

Measure	Time frame
Central Corneal Thickness	7 days

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 25, 2026