Connective Tissue Disease, Pulmonary Hypertension
Conditions
Brief summary
The purposes of this study are (I), to evaluate various screening methods for their ability to predict and to confirm Pulmonary Hypertension (PH) in scleroderma patients, and (II) to evaluate the incidence of PH (i.e. the number of new cases per year) in scleroderma patients.
Interventions
None listed
Sponsors
Heidelberg University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* consent form * men and women\> 18 years * fulfill the current definition of a collagen vascular disease according to the actual guidelines of the American College of Rheumatology (ACR)
Exclusion criteria
* all contraindications for exercise testing * significant restriction of the left ventricle, unstable coronary artery disease and myocardial infarction in the last 6 months * patients with other lung diseases (as the pulmonary infestations as part of systemic disease) or related musculoskeletal disorders influencing baseline exercise capacity * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of various screening methods for their ability to predict and to confirm PH in scleroderma patients | 3 years | Correlate Spiroergometric, lung functional Magnetic Resonance Imaging (MRI) and echocardiographic parameters with invasive hemodynamic findings collected by right heart catheterization: which other non-invasive parameters can be found to detect pulmonary hypertension? Can pulmonary hypertension be detected at rest in the echocardiography? In which patients can only stress-Doppler echocardiography confirm manifest or latent pulmonary hypertension? Is stress-Doppler echocardiography a suitable for early detection of pulmonary hypertension in patients with collagen vascular disease? |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Subdivision of patients with connective tissue disease in different degrees of severity | 3 years | Can spiroergometric findings help to subdivide patients with connective tissue diseases into groups according to degrees of severity, and differ the patients based on spiroergometric findings? To what extent is this distinction comparable with the classifications for the functional classes (application for PH according to the New York Heart Association (NYHA) classification) |
Countries
Germany
Contacts
Primary ContactEkkehard Grünig, MD, Prof.
Outcome results
None listed