Coronary Artery Bypass Surgery
Conditions
Keywords
hemodynamic stability, etomidate, ketamine, coronary artery bypass surgery after induction of anesthesia, hemodynamic stability
Brief summary
The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents regarding their effect on adrenal gland steroid synthesis in these patients.
Interventions
DRUGKetamine
During standard anesthesia induction with fentanyl and midazolam, ketamine 2 mg/kg IV will be administered
DRUGEtomidate
During standard anesthesia induction with fentanyl and midazolam, etomidate 3 mg/kg IV will be administered
Sponsors
Baskent University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for elective coronary artery bypass graft surgery with cardiopulmonary bypass * Patient's written informed consent for study participation * Ejection fraction ≥ 35%
Exclusion criteria
* Allergy to study drugs * Redo surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A more than 15% change in mean arterial pressure and heart rate after anesthesia induction | For 60 minutes after anesthesia induction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Adrenal gland steroid synthesis suppression | 24 hours and 5 days after study drug administration | A less than 9 microgram/dl increase in serum cortisol after stimulation with adrenocorticotropic hormone |
Countries
Turkey (Türkiye)
Contacts
Primary ContactÖzgür Kömürcü
Backup ContactArash Pirat
Outcome results
None listed