Stimulation in the Ovary
Conditions
Keywords
Metaphase II, Ovarian stimulation, Egg donors
Brief summary
The purpose of this study is to determine the efficacy and safety of two new patterns of controlled ovarian hyperstimulation (defined as total number of picked up eggs). This study will be performed in egg donors but these new patterns will be implemented in fertility preservation patients.
Interventions
PROCEDUREEarly luteal phase
We will administer in the tenth day of the cycle 0.25mg/day of ganirelix until the estradiol levels will be less than 60pgr/mL. Then, we'll start a standard protocol of controlled ovarian hyperstimulation beginning with 150 UI/day. At 6th day of stimulation we'll begin with the antagonist.
PROCEDURELate follicular phase -COH-
We will administer in the 20th day of the cycle 0.25mg/day of ganirelix until the estradiol levels will be less than 60pgr/mL. Then, we'll start a standard protocol of controlled ovarian hyperstimulation beginning with 150 UI/day. At 6th day of stimulation we'll begin with the antagonist.
Sponsors
Parc de Salut Mar
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* premenopausal women 18-30 years old, with FSH levels \< 10mIU * irregular menstrual cycle * BMI between 12-28 * signed inform consent
Exclusion criteria
* Polycystic ovarian syndrome, gonadotropins allergy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of eggs | Participants will be followed after 1-3 hrs of follicular aspiration. | The results will be presented in one year, egg recipients will be followed until 12 weeks of pregnancy. |
Countries
Spain
Outcome results
None listed