Chronic Obstructive Pulmonary Disease
Conditions
Keywords
chronic obstructive pulmonary rehabilitation, COPD, non invasive ventilation, NIV, exercise capacity, pulmonary rehabilitation
Brief summary
The aim of the study is to find out if nocturnal non-invasive ventilation during pulmonary rehabilitation increases exercise capacity and quality of life more than pulmonary rehabilitation alone.
Interventions
PROCEDUREpulmonary rehabilitation
Sponsors
ResMed
Schön Klinik Berchtesgadener Land
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* confirmed diagnosis of COPD in stages GOLD III/ IV * receiving optimized medical treatment and long term oxygen therapy if needed * patients consent to participate in this trial * no treatment with NIV in the last 4 weeks * treatment with NIV in the last 4 weeks due to an acute exacerbation
Exclusion criteria
* treatment with NIV in the last 4 weeks (except due to an acute exacerbation) * Intolerance to perform NIV * Acute exacerbation at baseline or during PR * Hypercapnia \> pCO2 55mmHg * Inability to perform a 6 minute walking test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in 6 minute walking distance | day 1 and 25 | change in 6 minute walking distance from baseline to day 25 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in quality of life (chronic respiratory questionnaire, CRQ) | day 1 and 25 | change in CRQ-Score from baseline to day 25 |
| change quality of life (Saint George´s Respiratory Questionnaire, SGRQ) | day 1 and 25 | change in SGRQ-Score from baseline to day 25 |
Countries
Germany
Outcome results
None listed