Feasibility of VMAT and CBCT for Head and Neck Carcinomas

Feasibility of Volumetric Modulated Arc Therapy and Cone-Beam Computed Tomography for Head and Neck Carinomas: Analysis of Clinical Throughput and Patient Reported Outcomes.

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01384890

Enrollment

Registered

2011-06-29

Start date

2011-07-31

Completion date

2012-05-31

Last updated

2013-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and Neck Carcinoma

Brief summary

This will be a prospective longitudinal study describing clinical throughput metrics and patient reported quality of life outcome measures for patients undergoing Volumetric modulated arc therapy (VMAT) with and without Cone-beam computed tomography (CBCT) for head and neck carcinoma at the British Columbia Cancer Agency. 1. VMAT for the treatment of patients with HNC will provide opportunities for image-guided radiotherapy using CBCT online correction to reduce systematic and random error. 2. Analysis of patient reported quality of life outcomes during VMAT, with and without CBCT acquisition, will be hypothesis generating.

Interventions

RADIATIONVMAT with CBCT

volumetric modulated arc therapy (VMAT) with cone-beam computed tomography (CBCT) position verification

RADIATIONVMAT with kV-ray

Volumetric modulated arc therapy (VMAT) with kV-ray position verification

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Months to No maximum

Healthy volunteers

Inclusion criteria

* age greater than 18 years * undergoing radical radiation therapy for head and neck carcinoma at the BC Cancer Agency

Exclusion criteria

* treatment being offered is not for curative intent * patient has received previous radiation for head and neck cancer * patient has systemic lupus erythematosis or scleroderma * patients has other autoimmune connective tissue disorders

Design outcomes

Primary

Measure	Time frame	Description
Clinical efficiency for volumetric modulated arc therapy (VMAT) delivery	After patient treated	Prospective work-flow metrics describing clinical efficiency for volumetric modulated arc therapy (VMAT) delivery with and without cone-beam computed tomography (CBCT) acquisition at the BCCA, generated from time requirements for treatment verification and delivery. The time spent by the patients at each stage of radiation therapy delivery will be recorded, including; time in radiation bunker, time in immobilization frame, kV or CBCT acquisition and online correction time, and beam on time
Position verification	After patient treated	Summary description of position verification and online corrections for volumetric modulated arch therapy (VMAT) delivery with and without cone-beam computed tomography (CBCT)

Secondary

Measure	Time frame	Description
Quality of life	No time frame (ongoing)	European Organization for Research and Treatment of Cancer Quality of Life Questionnaire for Head and Neck Cancer (EORTC QLQ - HN35) (23) (see Appendix V) and State Trait Anxiety Index (STAI)

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026