Acute Coronary Syndrome
Conditions
Brief summary
Patients undergoing multivessel off-pump coronary bypass surgery (OPCAB) inevitably experience cumulative ischemia-reperfusion injury at myocardium. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion on myocardium in patients undergoing OPCAB. Patients undergoing OPCAB with acute coronary syndrome are randomly assigned to GIK or Control group. The trial is double-blind and conducted at a single center.
Interventions
DRUGGIK solution
Patients receive 0.3 ml/kg/hr GIK solution or the same volume of normal saline depending on the group during off-pump coronary bypass surgery. GIK solution consist of 50% glucose, potassium 80 mEq, and regular insulin 325 IU/500ml.
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing isolated OPCAB. * Age: 20\ 75.
Exclusion criteria
* Emergency operation. * Patients with MR ≥ 2. * Patients with IDDM. * Patients with random sugar ≥ 250 mg/dL. * Patients with serum creatinine ≥ 2.0 mg/dL. * Patients with acute myocardial infarction within 1 week of surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CK-MB(creatinine kinase-MB) mass | 12 hours after the surgery | Comparison of cardiac enzyme elevation after surgery between GIK and Control group. |
Countries
South Korea
Outcome results
None listed