Heart Valve Disease
Conditions
Brief summary
Ischemia/reperfusion (I/R)-induced acute kidney injury is a serious complication affecting patient outcome following cardiovascular surgeries. Propofol, an intravenously administered anesthetic with antioxidant properties, protects organs from I/R injury. This study aimed to investigate the ability of propofol to protect kidneys against I/R injury in the patients undergoing valvular heart surgery.
Interventions
DRUGPropofol
Induction of anesthesia: Propofol 1 mg/kg, sufentanil 1.0-3.0 µg/kg and rocuronium 50 mg IV Maintenance of anesthesia (pre CPB): Propofol 120-600 µg ∙ kg-1 ∙ h-1 , sufentanil 0.15-0.3 µg ∙ kg-1 ∙ h-1, vecuronium 8-10 mg/h IV infusion Maintenance of anesthesia (during CPB): Propofol 120-600 µg ∙ kg-1 ∙ h-1 IV infusion Weaning from CPB: Sufentanil 50 µg IV Maintenance of anesthesia (post CPB): Propofol 120-600 µg ∙ kg-1 ∙ h-1 , sufentanil 0.15-0.3 µg ∙ kg-1 ∙ h-1, vecuronium 8-10 mg/h IV infusion Propofol infusion rate is titrated using bispectral index (40-60).
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing valvular heart surgery. * Age: 20\ 75.
Exclusion criteria
* Emergency operation. * Patients with vitamin E or vitamin C within 5 days before surgery. * Patients with preoperative C-reactive protein (CRP) \> 16 mg/L. * Patients with serum creatinine ≥ 2.0 mg/dL * Patients under hemodialysis. * Patients with acute myocardial infarction within 1 week before surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum creatinine | incidence of AKI during 48 hours after the surgery incidence of AKI | Comparison of serum creatinine elevation after surgery between Propofol and Control group. |
Countries
South Korea
Outcome results
None listed