Alzheimer Disease
Conditions
Brief summary
Cognitive and memory disorders are characterized of Alzheimer disease. In addition, psychologic and behavioural symptoms, called speak neuropsychiatric symptoms, are frequents and play an important role in prognostic and intervention. These symptoms are noticed before the diagnostic of dementia, their prevalence and their intensity increase with the evolution of disease. Apathy, which is characterized by a decrease of motivation, is the most frequent of this behaviour disrupt. Clinically, a decrease, or a totally, lack of interest, initiative and blunting emotional are noticed. Fundamentally, apathy is considered as a decrease of cognition and behaviour to go in goal. Assessment of psychological and behavioural symptoms is realised principally with neuropsychiatric scales. These contribute to obtain particular informations about health of patient allowing by patient and caregiver discussions and impressions of clinician. These scales are simples but loss of subjectivity. An alternative of this method is the use of gerontechnology as actigraphy (system out-patient which records locomotive activity with the help of piezo-electrical sensor fixed on a bracelet) and video recording which is associated to an informatic treatment of signal in order event recognition. The aim of study is to realise an objective assessment of activities go in goal during experimental sequence which has well-characterized acts, using at the same time an actigraphic record of activity motive (system of assessment indirect of apathy fit) and a video records which uses an informatic event recognition system. The assessment will realise with participants controls (n=30) and Alzheimer disease patients with (n=20) or without (n=20) apathy, during well-characterized records. The final aim is to obtain a particular assessment of some disorders behaviours, as apathy, which is principally characterize by a decrease of behaviours to go in goal.
Interventions
OTHERobservational
Observation during a physical exercise
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for no mnesic patient: * man or female, more 65 years ; * no caregiver ; * no motor handicap ; * no global cognitive impairment with \> 26 MMSE, neither argument in favour of following diagnosis : Alzheimer's disease, major depressive episode ; * no apathy ; * participant with french national health ; * signature of informed consent. Inclusion Criteria for Alzheimer's patient: * man or female, more 65 years ; * no motor handicap ; * with diagnosis of Alzheimer's disease according to criteria of NINCDS-ADRDA ; * apathy score \> 3 in Neuropsychiatric Inventory ; * with a MMSE score lower than 26/30 ; * with cholinesterase inhibitor medication, standard and stable dose since 3 month ; * no global cognitive impairment with \> 26 MMSE, neither argument in favour of following diagnosis : Alzheimer's disease, major depressive episode ; * no apathy ; * participant with french national health ; * signature of informed consent.
Exclusion criteria
* Impossibility of realization of the experimental protocol because of a driving handicap. * Port(Bearing) of a pacemaker * Under guardianship Patient or guardianship
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| stride and speed walking | one time point - at the only visit of protocol (day 1) |
Secondary
| Measure | Time frame |
|---|---|
| For comparison between Alzheimer disease patients with (n=20) or without apathy, we use again stride and speed walking | one time point - at the only visit of protocol (day 1) |
| For reproducibility, we use stride and speed walking | one time point - at the only visit of protocol (day 1) |
| Reliability is the sum of posture's concordance | one time point - at the only visit of protocol (day 1) |
| Relation between LF/HF variations and activity index | one time point - at the only visit of protocol (day 1) |
Countries
France
Outcome results
None listed