Bipolar Disorder, Schizophrenia
Conditions
Brief summary
Aim: The purpose of the study is to characterize the at-risk phases preceding a first episode of bipolar disorder and of schizophrenia, and to identify clinical and biological predictors of the disease development. Hypothesis a: Over 6-24 months, 25% of at-risk youth will develop the full manifestations of Bipolar Disorder (BPD) or schizophrenia. Hypothesis b: The symptoms utilized for characterizing the at-risk phase of BPD will differentiate between individuals developing BPD and schizophrenia.
Detailed description
Prospective, naturalistic, cohort study aiming to characterizing the bipolar and psychotic prodrome thoroughly with a variety of clinical and biological measures.
Interventions
None listed
Sponsors
Northwell Health
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age: 12-18 years; 2. Sex: male or female; 3. Race/ethnicity: no restrictions; 4. Definite or suspected chart diagnosis of BP-II, BP-NOS, cyclothymia, MDD, depressive disorder NOS, dysthymia or mood disorder NOS, schizophrenifiorm disorder or psychotic disorder NOS; 5. Subject and parent (if subject\<18) willing and able to provide written, informed consent/assent.
Exclusion criteria
1. Estimated Premorbid IQ \< 70; 2. Meets DSM-IV criteria for BP-I or schizophrenia, pervasive developmental disorder, autism spectrum disorders, current substance dependence; 3. History of medical condition known to affect the brain; 4. current group home affiliation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of subjects with development of a bipolar or schizophrenia disorder | within 60 months | Diagnostic conversion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Psychopathology | within 60 months | Psychopathology |
Countries
United States
Outcome results
None listed