Deglutition Disorders
Conditions
Brief summary
Piperine acts on the oropharyngeal TRPV1, increasing sensory input and the release of substance P. These actions may accelerate the oropharyngeal swallow response, improving the swallowing of dysphagic patients.
Interventions
DRUGPiperine
Sponsors
Hospital de Mataró
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age\>18 * History of swallowing difficulties associated with aging and/or neurological diseases (neurodegenerative or non-progressive neurological diseases) * Study explained and written subject information given * Informed consent signed
Exclusion criteria
* Patients suffering idiosyncratic phenomena or who are allergic to any medication, especially iodinated contrast media * Patients suffering major respiratory disease or undergoing any type of surgery in the three months prior to the study * Patients with a background of alcohol dependence or other drug dependence * Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Safety of swallow | 15 minutes | Prevalence of penetrations at the laryngeal vestibule |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of swallow | 15 minutes | Prevalence of oral and pharyngeal residue |
Countries
Spain
Outcome results
None listed