Women With Polycystic Ovary Syndrome Have Increased Plasma Chitotriosidase Activity

Women With Polycystic Ovary Syndrome Have Increased Plasma Chitotriosidase Activity: A Pathophysiological Link Between Inflammation and Impaired Insulin Sensitivity?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01382576

Enrollment

Registered

2011-06-27

Start date

2010-01-31

Completion date

2010-12-31

Last updated

2012-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic Ovary Syndrome

Keywords

polycystic ovary syndrome, chitotriosidase activity

Brief summary

In the present study, serum chitotriosidase activity and its relationship with insulin resistance were determined in patients with Polycystic Ovary Syndrome (PCOS).

Detailed description

ChT activity is increased in patients with PCOS in concordance with insulin resistance. These findings may reflect the pronounced risk for metabolic syndrome and atherosclerotic diseases in this particular patient group.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Absence of significant abnormalities on physical examination except hirsutism * no lipid lowering, hypoglycemic, antihypertensive or hormone replacement therapy * normal thyroid function and prolactin level * absence of history or evidence of metabolic, cardiovascular, respiratory or hepatic disease

Exclusion criteria

* Pregnant * ovarian tumors * congenital adrenal hyperplasia or BMI greater than 30 kg/m2

Countries

Turkey (Türkiye)

Outcome results