Coronary Artery Disease
Conditions
Keywords
clinical indication for myocardial SPECT, suspected or known coronary artery disease
Brief summary
Ionizing radiation has a number of harmful effects in humans. The most important among these is the induction of cancer. It is assumed that damage to DNA in the nucleus of a single cell can induce cancer. Among the different types of lesions inducted, DNA double-strand breaks (DSBs) are considered to be the most relevant effects that can initiate carcinogenesis. The investigators are already conducting several other studies to prospectively compare the inducted DSBs by coronary CT-angiography and conventional coronary angiography. Extending these examinations to investigate the induced DSBs by myocardial scintigraphy allows a comparison of all three relevant imaging methods of the heart that incorporate ionizing radiation. To evaluate this, the investigators are planning to examine patients who are scheduled for a clinically indicated myocardial scintigraphy. These examinations are routinely done by the Department of Nuclear Medicine in either a 1-day or a 2-day protocol according to the diagnostic reference values of the Federal Department for Radiological Protection. Blood samples will be taken from these patients at predefined time steps before and after the examination and DNA double-strand breaks will be determined from these blood samples specifically considering the applied activity of the tracer and the exposition kinetics.
Interventions
RADIATIONMyocardial SPECT
Myocardial SPECT according to clinical standards for patients with a clinical indication to undergo this imaging test.
Sponsors
Charite University, Berlin, Germany
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* myocardial SPECT clinically indicated
Exclusion criteria
* acute leukaemia or lymphoma * radiation or chemotherapy in the last 6 months * x-ray or scintigraphy within the last 3 days * age below 18 years * eGFR of below 60 ml/min
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiation-induced DNA double-strand breaks after myocardial scintigraphy. | 48 hours | DNA double-strand breaks will be measured before and up to 48 hours after radiation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of radiation-induced DSBs with activity used for myocardial scintigraphy. | Activity will be measured 5 min and 1h after injection of the technetium tracer for SPECT. | DNA double-strand breaks will be compared with injected activity. |
Countries
Germany
Outcome results
None listed