Alpha-1-antitrypsin-deficiency, Chronic Obstructive Pulmonary Disease
Conditions
Keywords
alpha-1-antitrypsin-deficiency, COPD, exercise training, muscle biopsy
Brief summary
Chronic Obstructive Pulmonary Disease (COPD)-patients (caused by smoking-level) and Alpha-1-Antitrypsin-deficiency patients showed different developments during rehabilitation in regard to improvement of 6-minute-walking distance. The aim of this study is to investigate differences between training adaptations in COPD-patients and Alpha-1-deficiency patients. Both groups take part in a standardized multimodal 3-week-rehabilitation with strength and endurance training. In addition to conventional diagnostic procedures, muscle biopsies from the M. vastus lateralis will be conducted before and after rehabilitation program followed by biochemical, histochemical and immunohistochemical analysis of the probes.
Interventions
PROCEDUREexercise training
strength and endurance training, 5 time per week.
Sponsors
Grifols Therapeutics LLC
Alpha-1 Foundation
Schön Klinik Berchtesgadener Land
Study design
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* COPD * Alpha-1-Antitrypsine-deficiency, phenotype: ZZ * FEV1%pred. \<50
Exclusion criteria
* acute exacerbation * exacerbation in the last 4 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| aerobic and anaerobic enzymes | day 2 and 23 | changes in quantity of enzymes from baseline to day 23 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| maximal exercise capacity in incremental cycling test | day 2 and 23 | Change in max. exercise capacity from baseline to day 23 |
| 6-minute-walking distance | day 3 and 24 | change in 6-minute-walking distance from baseline to day 24 |
Countries
Germany
Outcome results
None listed