Vecuronium Requirements According to the Operation Phase During Liver Transplantation Under Desflurane Anesthesia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01379352

Enrollment

Registered

2011-06-23

Start date

2011-06-30

Completion date

2011-12-31

Last updated

2013-12-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplantation

Keywords

liver transplantation, vecuronium

Brief summary

The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may also be different according to the preoperative hepatic function as measured by MELD score during prehepatic phase, or graft to recipient body weight ratio (GRWR) during neohepatic phase. Therefore, the investigators are trying to investigate the difference of vecuronium requirements according to the phase of surgery or MELD score, GRWR.

Detailed description

The vecuronium requirements may be reduced for recipients of living donor liver transplantation, as the vecuronium is eliminated principally by the liver. Furthermore, the requirements may be different according to the phase of surgery. The requirements may by further reduced during anhepatic phase of liver transplantation. And the requirements may be increased as the graft functions during neohepatic phase. We also postulated that the requirements may be different according to the preoperative hepatic function during preanhepatic phase, and according to the graft to recipient body weight ratio (GRWR) during neohepatic phase. Therefore, we are trying to investigate the difference of vecuronium requirements according to the phase of surgery, MELD score, GRWR.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 69 Years

Healthy volunteers

Inclusion criteria

* patients undergoing elective living donor liver transplantation

Exclusion criteria

* patients who can not undergo train-of-four test due to central or peripheral neuromuscular disease. * patients with severe cardiopulmonary diseases. * patients who received transfusion with more than 10 units of packed red blood cells. * primary non-functioning graft immediately after reperfusion of the graft. * patients who administered drugs that influences the metabolism of vecuronium (such as anticonvulsant: phenytoin, carbamazepine, primidone, sodium valproate) * patients undergoing cadaver donor liver transplantation

Design outcomes

Primary

Measure	Time frame	Description
vecuronium requirements during preanhepatic phase	during prehepatic phase of liver transplantation	total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during preanhepatic phase
vecuronium requirements during anhepatic phase	during anhepatic phase of liver transplantation	total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during anhepatic phase
vecuronium requirements during neohepatic phase	during neohepatic phase of liver transplantation	total vecuronium requirements as guided by Train-of-four neuromuscular monitoring during neohepatic phase

Countries

South Korea

Outcome results