Volatile Organic Compounds in Staphylococcus Aureus Patients

Detection of Methicillin Resistant Staphylococcus Aureus Colonization Using the zNose®, an Ultra-fast Gas Chromatograph

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01379053

Acronym

MRSAVOC

Enrollment

Registered

2011-06-23

Start date

2009-08-31

Completion date

2010-12-31

Last updated

2014-08-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Methicillin-resistant Staphylococcus Aureus, Nosocomial Disease, Staphylococcus Aureus

Keywords

Staphylococcus aureus, Methicillin-resistant staphylococcus aureus, Nosocomial disease, Electronic nose, Gas chromatography

Brief summary

The zNose® MRSA test is a non-invasive breath test for markers of Staphylococcus aureus, which may predict the probability of bacterial organisms in the anterior nares, throat and respiratory tract, wounds, and anus and therefore be able to replace or supplement current active Methicillin Resistant Staphylococcus Aureus (MRSA) surveillance efforts. It consists of: * A collection apparatus for collection of volatile compounds from suspected infection sites onto a sorbent trap or Tedlar bag, as well as for the collection of a separate sample of room air. * Analysis of the volatile organic compounds from suspected infection sites and room air by short acoustic wave gas chromatography. * Interpretation of the volatile organic compounds with a proprietary algorithm in order to predict the probability of Staphylococcus aureus infection and colonization. This study will test the hypothesis that we can identify the presence of MRSA by sampling the head space above culture media of anterior nare samples provided by patients with MRSA. Additionally, this study will test the hypothesis that we can identify the presence of MRSA by sampling air exhaled through the nostrils (nasal exhalant).

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* Suspicion of staphylococcus aureus infection or colonization * Able to give samples for zNose® analysis

Exclusion criteria

* Inability to provide sample for zNose® analysis

Design outcomes

Primary

Measure	Time frame	Description
Identification of Methicillin Resistant Staphyloccus aureus	one week	Identification during clinic visit of MRSA

Countries

United States

Outcome results