Transcranial Direct Current Stimulation (tDCS) for Treatment of Negative Syndrome in Patients With Schizophrenia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01378078

Enrollment

Registered

2011-06-22

Start date

2011-06-30

Completion date

2013-06-30

Last updated

2013-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Keywords

schizophrenia, negative syndrome, PANSS

Brief summary

Transcranial direct current stimulation (tDCS) showed beneficial effects on cognition in healthy subjects and depressed patients. In this study, patients with treatment resistant negative syndrome in schizophrenia will be treated with direct current stimulation. fMRI measures will be performed.

Interventions

DEVICEeldith DC-stimulator (neuroconn, Ilmenau, Germany)

daily tDCS treatment over left DLPFC, 20 min, 2 mA

DEVICEeldith DC-stimulator (Neuroconn, Ilmenau, Germany)

same as sham stimulation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* schizophrenic patients with a negative syndrome. PANSS \> 40.

Exclusion criteria

* other psychiatric or neurologic diseases.

Design outcomes

Primary

Measure	Time frame	Description
SANS reduction	4 weeks after baseline	decrease by 30%

Secondary

Measure	Time frame	Description
neuropsychological tests	4 weeks after baseline	increase in SOPT by 30% increase in TMT by 30%

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026