DNA Methylation and Urothelial Carcinoma

Level of DNA Methylation in People With Urothelial Carcinoma

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01378052

Enrollment

200

Registered

2011-06-22

Start date

2011-06-30

Completion date

Unknown

Last updated

2011-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urothelial Carcinoma

Brief summary

Many studies previously showed the significant association between urinary arsenic profiles and urothelial carcinoma (UC) risk and observed the increased UC risk in people with lower plasma folate and higher homocysteine than those with higher plasma folate and lower homocysteine. The investigators would expect to explore the interactions among global DNA methylation, one-carbon metabolic pathway factors, urinary arsenic profiles and UC.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of urothelial carcinoma * The voluntary of participating the study

Exclusion criteria

* Age smaller than 20 years * Pregnant women * Not willing to participate the study because of their personal reasons

Design outcomes

Primary

Measure	Time frame	Description
urothelial carcinoma	one year	Pathological verification of UC was done by routine urological practice including endoscopic biopsy or surgical resection of urinary tract tumors followed by histopathological examination by board-certified pathologists.

Countries

Taiwan

Contacts

Primary ContactChao-Hsiang Chang, PhD

urology8395@yahoo.com.tw886-4-22052121

Outcome results