Peripheral Arterial Disease
Conditions
Brief summary
Contrast ultrasound is a technique that can quantify blood flow in the tissues of the body by ultrasound detection of microbubble contrast agents that behave in the circulation similar to red blood cells. In this study, the investigators hypothesize that contrast ultrasound of blood flow in the leg (thigh and calf) at rest and during stress produced by medications that mimic exercise (vasodilator stress) can provide information on the location and severity of peripheral vascular disease (blockages of the blood vessels in the leg). The investigators will also determine whether symptom improvement after revascularization (procedures to open up or bypass the blockages) is directly related to the improvement in blood flow.
Interventions
None listed
Sponsors
Oregon Health and Science University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Known or suspected PAD 2. Lower extremity angiography or MRA planned or performed within 6 months
Exclusion criteria
1. Age \<19 y.o. 2. Pregnant or lactating females 3. Hypersensitivity to ultrasound contrast agent, dipyridamole, or regadenoson 4. Severe reactive airways disease 5. Evidence right-to-left shunt (identified on screening echo) 6. NYHA Class III or IV heart failure. 7. Planned amputation 8. Unstable coronary artery disease or severe aortic stenosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantitation of Perfusion | Immediate | Correlation of skeletal muscle perfusion with symptom status |
Countries
United States
Outcome results
None listed