Effects of a Chewing Gum Containing POs-Ca and Fluoride on Enamel

Effects of a Chewing Gum Containing POs-Ca and Fluoride on Remineralization of Enamel Subsurface Lesions in Situ

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01377493

Enrollment

Registered

2011-06-21

Start date

2009-12-31

Completion date

2011-06-30

Last updated

2011-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Enamel Subsurface Lesion

Keywords

chewing-gum, enamel subsurface lesion, calcium additives, fluoride, in situ

Brief summary

There were no differences in the degree of enamel remineralization of subsurface lesions among the chewing gums containing or not containing POs-Ca and fluoride.

Interventions

DIETARY_SUPPLEMENTchewing gum

chewing gum containing no active ingredients, or Ca-P bioavailable ions, or Ca-P and F bioavailable ions

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 31 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy adult subjects * More than 22 permanent teeth

Exclusion criteria

* Alcohol addiction * Smoking * Active caries * Periodontal pockets * Low-saliva flow (less than 0.3ml/min)

Design outcomes

Primary

Measure	Time frame	Description
Mineral content of enamel	2 weeks	Mineral content of bovine enamel blocks inserted into the subject mouth during chewing of the gums was assessed.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 28, 2026