Caffeine Withdrawal, Cerebral Haemodynamics, Cognitive Function, Mood
Conditions
Keywords
Caffeine, Withdrawal, Cognitive function, Mood, Cerebral haemodynamics
Brief summary
The purpose of this study is to determine the effects of 2 weeks caffeine abstinence as compared to 2 weeks caffeine maintenance (300mg per day)on cognition and mood. Cerebral blood flow effects will also be assessed in a subset of participants. The role of caffeine abstinence/maintenance in the acute effects of caffeine will also be explored.
Detailed description
The current randomised, placebo-controlled, double-blind, parallel groups study aims to explore the behavioural effects of 2-weeks caffeine abstinence as well as establishing the role of abstinence in the effects of caffeine administration by administering caffeine or placebo to those in a state of chronic and acute abstinence. This research also aims to explore, in a subset of participants, the cerebral blood flow effects of caffeine abstinence and caffeine administration using Near Infrared Spectroscopy (NIRS). Cerebral blood flow will be measured both at rest and during performance of cognitive tasks.
Interventions
DIETARY_SUPPLEMENTPlacebo
Inert placebo containing silica powder CAB-O-SIL-M-5Pharma (Pharmaceutical grade)CABOT GmbH. 1 Size 0 capsule 3 times a day for 14 days and 1 size 0 capsule on day 15.
DIETARY_SUPPLEMENTCaffeine and Placebo
100 mg Caffeine capsules 3 times per day for 14 days and 1 size 0 capsule of inert placebo containing silica powder CAB-O-SIL-M-5Pharma (Pharmaceutical grade)CABOT GmbH on day 15.
DIETARY_SUPPLEMENTPlacebo and Caffeine
Inert placebo capsules containing silica powder CAB-O-SIL-M-5Pharma (Pharmaceutical grade)CABOT GmbH, 1 Size 0 capsule 3 times a day for 14 days and a 100mg caffeine capsule on day 15.
DIETARY_SUPPLEMENTCaffeine
Capsule containing 100 mg caffeine, one 3 times a day for 14 days and then one capsule on day 15.
Sponsors
Northumbria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Male/Female * 18 - 40 years * Healthy * Consume ≥ 150 mg caffeine daily * No herbal supplements/prescription medications (excl. contraceptive pill) * Non smoker * Native English speaker
Exclusion criteria
* Diagnosis of any significant medical condition or disorder * Any known allergy or hypersensitivity to food. * BMI \>29.9 or \<18.5 * Blood pressure \>139/89
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive performance | 2 weeks | Performance is assessed using COMPASS (Computerised Mental Performance Assessment System), which presents a battery of standard cognitive tasks assessing aspects of attention and memory. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mood | 2 weeks | Mood will be evaluated using Visual Analogue Scales administered using COMPASS. |
| Cerebral haemodynamic | 2 weeks | Cerebral blood flow will be measured in a subset of participants using Near Infrared Spectroscopy (NIRS). |
| Sleep | 2 weeks | Quality of sleep will be measured using the Pitsburgh Sleep Quality Index (PSQI). |
| Caffeine withdrawal | 2 weeks | Symptoms of caffeine withdrawal will be measured using a Subjective and Somatic State Questionnaire. |
Countries
United Kingdom
Outcome results
None listed