Respiratory Insufficiency
Conditions
Keywords
acute respiratory distress syndrome, acute lung injury, cerebrovascular autoregulation, transcranial Doppler, ventilation
Brief summary
The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.
Detailed description
Cerebral blood flow velocity will be measured using transcranial Doppler sonography and then correlate with the invasive arterial blood pressure curve to calculate the index of cerebrovascular autoregulation Mx (Mx\>0.3 indicates impaired AR). The index of cerebrovascular autoregulation Mx was measured during baseline positive end-expiratory pressure (PEEP) levels and after lung recruitment with higher level of PEEP. The equality between this two PEEP levels was estimated and calculated with one side Wilcoxon test.
Interventions
PROCEDUREpositive end-expiratory pressure
Elevation of positive end-expiratory failure for recruitment
Sponsors
Johannes Gutenberg University Mainz
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* respiratory failure * Age \>18 years * Invasive ventilation
Exclusion criteria
* Sepsis * preexisting cerebral illness * traumatic brain injury * meningitis or encephalitis * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Integrity of the cerebrovascular autoregulation (CA) | 30 Minutes | Cerebrovascular autoregulation will be calculated as a moving correlation index (Mx) from the cerebral blood flow velocity and the arterial blood pressure. It is a parameter without unit (index). |
Countries
Germany
Outcome results
None listed