Modulation of Cerebral Blood Flow Using Quercetin, a Nutritional Supplement

Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular Aging

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01376011

Acronym

Quercetin

Enrollment

106

Registered

2011-06-20

Start date

2009-06-30

Completion date

2014-12-31

Last updated

2015-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Problem of Aging, Stroke

Keywords

quercetin, brain blood flow, aging, memory

Brief summary

The purpose of this study is to find out if quercetin can increase blood levels of hypoxia-inducible transcription factor 1 (HIF-1 protein) and to see if there is a corresponding increase in blood flow to the brain.

Interventions

DIETARY_SUPPLEMENTquercetin/placebo

Quercetin 500mg once per day versus placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy volunteers between the ages of 18-75 years old

Exclusion criteria

* subjects taking vasoactive medications * hypertension or vascular disease * asthma * smokers * pregnant women * cancer * diabetes mellitus * history of seizures * history of stroke or head trauma * subjects taking digoxin, cyclosporine,felodipine, estradiol, or quinolone antibiotics * poor transcranial Doppler insonation windows

Design outcomes

Primary

Measure	Time frame	Description
Define change from baseline levels of HIF-1 concentration and 3 of its regulated proteins after 6 months of quercetin (versus placebo) dietary intake.	6 months	Baseline and 6 month blood samples will be analyzed for levels of HIF-1, VEGF, EPO, and NOS
Determine change from baseline brain blood flow after 6 months of quercetin (versus placebo) dietary intake.	6 months	Determine cerebral vasomotor reactivity response to 6 months of quercetin intake by measuring changes in middle cerebral artery (MCA) blood flow velocity in response to changes in end-tidal CO2, and assess neurovascular coupling by measuring changes in MCA flow velocity in response to neuropsychological tasks.

Secondary

Measure	Time frame	Description
Define change from baseline performance in a battery of cognitive tasks after 6 months of quercetin (versus placebo) dietary intake.	6 months	Assess effects of 6 months of quercetin intake on cognitive function using a cognitive battery designed to asses both memory and executive function.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026