Cognitive Ability, General
Conditions
Keywords
Cognitive function, Experimental pain
Brief summary
Patients with chronic pain can experience considerable changes in their cognitive function such as forgetfulness, increased absentmindedness, confusion etc. Opioids (e.g. morphine and morphine-like analgesics) are often used in treatment of acute and chronic pain and can lead to worsening of the cognitive function. The interaction between pain, treatment and cognitive function is very complex and is far from understood. The hypothesis of the present study is that by use of experimental pain in healthy volunteers it will be possible to elucidate the interaction between pain, treatment and cognitive function.
Interventions
DRUGUltiva (remifentanil) or placebo
0.1microg/kg/min remifentanil administered as infusion Max infusion time is 20min
Sponsors
Mech-Sense
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men aged 18-65 years * Normal vision and hearing * No disease associated with cognitive dysfunction
Exclusion criteria
* Allergic to remifentanil or patches * Any use of pain killers or alcohol 48hours before study start * Current participation in other clinical studies or participation within the last 14days before study start * Prescribed medication * Risk of developing * Previously alcohol- or drug addict * MMSE score \< 26
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive function | 3 experiments each lasting for about 4-6hours - total duration of study is around 8-9month | Investigate the relationship between cognitive function and pain and treatment with remifentanil |
Countries
Denmark
Outcome results
None listed