ED50 of Dexmedetomidine to Prevent Emergence Agitation in Children

ED50 of Dexmedetomidine for Reduction of Emergence Agitation Incidence Undergoing Tonsillectomy or Adenoidectomy in Desflurane Anesthesia Following Sevoflurane Induction in Children

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01374737

Enrollment

Registered

2011-06-16

Start date

2011-06-30

Completion date

2012-02-29

Last updated

2011-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Agitation

Brief summary

There are several recommended doses of dexmedetomidine for prevention of emergence agitation in children. In this study, the investigators examine ED50 in prevention of emergence agitation after tonsillectomy or adenoidectomy in children.

Detailed description

To investigate ED50, Dixon's up and down method will be used.

Interventions

DRUGDexmedetomidine

dexmedetomidine, 0.1ug/kg up or down

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

2 Years to 12 Years

Healthy volunteers

Inclusion criteria

* tonsillectomy or adenoidectomy

Exclusion criteria

* recent URI

Design outcomes

Primary

Measure	Time frame
agitation	30 minutes

Secondary

Measure	Time frame
pain	30 minutes

Countries

South Korea

Contacts

Primary ContactHee-Soo Kim, M.D., PhD

dami0605@snu.ac.kr82220723659

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026