Importance of Meal Fat Content and Gall Bladder Emptying for Postprandial GLP-1 Secretion in Type 2 Diabetes Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01374594

Enrollment

Registered

2011-06-16

Start date

2011-06-30

Completion date

2012-11-30

Last updated

2013-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Brief summary

PURPOSE The goal of the present project is to unravel the importance of bile acid-induced GLP-1 secretion (via the G protein-coupled receptor TGR5) in human physiology. In the present study the investigators examine the GLP-1 secretion in healthy subjects and in Type 2 Diabetes Mellitus (T2DM) patients. The investigators hypothesize that patients with T2DM of relatively long duration will be characterized by reduced gall bladder emptying, and, consequently, reduced intestinal TGR5 activation; resulting in attenuated postprandial GLP-1 responses (primary endpoint).

Interventions

None listed

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

(Healthy) * HbA1 \< 6 % * Normal haemoglobin levels * Informed content Inclusion Criteria: (T2DM) * T2DM \> 5 years * Normal haemoglobin levels * Informed content

Exclusion criteria

(T2DM) * Treatment with insulin, DPP-IV inhibitor or GLP-1 analogues * Obesity (BMI \> 30) * Age \> 70 years * Gastrointestinal disease * Nephropathy * Liver disease * Medication which cannot be on hold for 12h * Gastrointestinal surgery

Design outcomes

Primary

Measure	Time frame
GLP-1 secretion	Postprandial

Countries

Denmark

Outcome results