Australian Multicentre Colonic Endoscopic Mucosal Resection Study

Conditions

Colonic Polyps

Brief summary

A prospective, multicentre, observational study of all patients referred for endoscopic resection of sessile colorectal polyps sized ≥20 mm conducted with intention to treat analysis.

Detailed description

A prospective, multicentre, observational study of all patients referred for endoscopic resection of sessile colorectal polyps sized ≥20 mm conducted with intention to treat analysis. Detailed data regarding lesion characteristics (size, location, Paris classification, granular or non-granular surface morphology and Kudo pit pattern), procedural, clinical and histological outcomes and complications are noted. Multivariate analysis will be performed to identify risk factors for Endoscopic Mucosal Resection failure and adenoma recurrence at follow-up colonoscopy.

Julia Gauci, Francesco Vito Mandarino, Clarence Kerrison, Anthony Whitfield, Timothy H. O’Sullivan et al. (13 authors)

Gut2025-03-054 citations

10.1136/gutjnl-2024-333563

Prevalence of Endoscopically Curable Low-Risk Cancer Among Large (≥20 mm) Nonpedunculated Polyps in the Right Colon.

Gauci JL, Whitfield A, Medas R, Kerrison C, Mandarino FV, Gibson D, O'Sullivan T, Cronin O, Gupta S, Lam B, Perananthan V, Hourigan L, Zanati S, Singh R, Raftopoulos S, Moss A, Brown G, Klein A, Desomer L, Tate DJ, Williams SJ, Lee EY, Burgess N, Bourke MJ.

2024-07-315 citations

10.1016/j.cgh.2024.07.017

Incomplete mucosal layer excision during EMR: a potential source of recurrent adenoma (with video).

Tate DJ, Vosko S, Bar-Yishay I, Desomer L, Shahidi N, Sidhu M, McLeod D, Bourke MJ.

2024-01-252 citations

10.1016/j.gie.2024.01.030

Safety and efficacy of physician-administered balanced-sedation for the endoscopic mucosal resection of large non-pedunculated colorectal polyps

Sunil Gupta, Rajiv Kurup, Neal Shahidi, Sergei Vosko, Owen McKay et al. (11 authors)

Endoscopy International Open2023-09-251 citations

10.1055/a-2180-8880

Treatment of adenoma recurrence after endoscopic mucosal resection

David J. Tate, Lobke Desomer, Maria Eva Argenziano, Neha Mahajan, Mayenaaz Sidhu et al. (11 authors)

Gut2023-07-0629 citations

10.1136/gutjnl-2023-330300

The Surface Morphology of Large Nonpedunculated Colonic Polyps Predicts Synchronous Large Lesions.

O'Sullivan T, Tate D, Sidhu M, Gupta S, Elhindi J, Byth K, Cronin O, Whitfield A, Craciun A, Singh R, Brown G, Raftopoulos S, Hourigan L, Moss A, Klein A, Heitman S, Williams S, Lee E, Burgess NG, Bourke MJ.

2023-02-124 citations

10.1016/j.cgh.2023.01.034

Comparison of the morphology and histopathology of large nonpedunculated colorectal polyps in the rectum and colon: implications for endoscopic treatment.

Cronin O, Sidhu M, Shahidi N, Gupta S, O'Sullivan T, Whitfield A, Wang H, Kumar P, Hourigan LF, Byth K, Burgess NG, Bourke MJ.

2022-02-2413 citations

10.1016/j.gie.2022.02.022

Impact of en bloc resection on long-term outcomes after endoscopic mucosal resection: a matched cohort study.

Tate DJ, Sidhu M, Bar-Yishay I, Desomer L, Brown G, Hourigan LF, Lee EYT, Moss A, Raftopoulos S, Singh R, Williams SJ, Zanati S, Burgess N, Bourke MJ.

2019-12-2814 citations

10.1016/j.gie.2019.12.025

Two-stage endoscopic mucosal resection is a safe and effective salvage therapy after a failed single-session approach

David J. Tate, Lobke Desomer, Luke F. Hourigan, Alan Moss, Rajvinder Singh et al. (6 authors)

Endoscopy2017-05-3121 citations

10.1055/s-0043-110671

Adenoma recurrence after piecemeal colonic EMR is predictable: the Sydney EMR recurrence tool.

Tate DJ, Desomer L, Klein A, Brown G, Hourigan LF, Lee EY, Moss A, Ormonde D, Raftopoulos S, Singh R, Williams SJ, Zanati S, Byth K, Bourke MJ.

2016-11-2896 citations

10.1016/j.gie.2016.11.027

Deep mural injury and perforation after colonic endoscopic mucosal resection: a new classification and analysis of risk factors

Nicholas G. Burgess, Milan S. Bassan, Duncan McLeod, Stephen J. Williams, Karen Byth et al. (6 authors)

Gut2016-07-27217 citations

10.1136/gutjnl-2015-309848

Prophylactic clipping for the prevention of bleeding following wide-field endoscopic mucosal resection of laterally spreading colorectal lesions: an economic modeling study

Farzan F. Bahin, Khalid N. Rasouli, Stephen J. Williams, Eric Lee, Michael J. Bourke

Endoscopy2016-04-2536 citations

10.1055/s-0042-105558

Endoscopic resection of subtotal or completely circumferential laterally spreading colonic adenomas: technique, caveats, and outcomes

Nicholas Tutticci, Amir Klein, Rebecca Sonson, Michael J. Bourke

Endoscopy2016-03-2328 citations

10.1055/s-0042-101854

Endoscopic mucosal resection for large serrated lesions in comparison with adenomas: a prospective multicentre study of 2000 lesions

María Pellisé, Nicholas G. Burgess, Nicholas Tutticci, Luke F. Hourigan, Simon Zanati et al. (16 authors)

Gut2016-01-19128 citations

10.1136/gutjnl-2015-310249

Cost Analysis of Endoscopic Mucosal Resection vs Surgery for Large Laterally Spreading Colorectal Lesions.

Jayanna M, Burgess NG, Singh R, Hourigan LF, Brown GJ, Zanati SA, Moss A, Lim J, Sonson R, Williams SJ, Bourke MJ.

2015-09-11154 citations

10.1016/j.cgh.2015.08.037

The influence of clips on scars after EMR: clip artifact.

Pellisé M, Desomer L, Burgess NG, Williams SJ, Sonson R, McLeod D, Bourke MJ.

2015-09-1023 citations

10.1016/j.gie.2015.08.071

Endoscopic mucosal resection of laterally spreading lesions involving the ileocecal valve: technique, risk factors for failure, and outcomes

Kavinderjit S. Nanda, Nicholas Tutticci, Nicholas G. Burgess, Rebecca Sonson, Stephen J. Williams et al. (6 authors)

Endoscopy2015-03-1263 citations

10.1055/s-0034-1391732

Clinical and endoscopic predictors of cytological dysplasia or cancer in a prospective multicentre study of large sessile serrated adenomas/polyps

Nicholas G. Burgess, María Pellisé, Kavinderjit S. Nanda, Luke F. Hourigan, Simon Zanati et al. (15 authors)

Gut2015-03-0296 citations

10.1136/gutjnl-2014-308603

Long-term adenoma recurrence following wide-field endoscopic mucosal resection (WF-EMR) for advanced colonic mucosal neoplasia is infrequent: results and risk factors in 1000 cases from the Australian Colonic EMR (ACE) study

Alan Moss, Stephen J. Williams, Luke F. Hourigan, Gregor J. Brown, William Tam et al. (11 authors)

Gut2014-07-01494 citations

10.1136/gutjnl-2013-305516

Interventions

PROCEDUREEndoscopic Mucosal Resection

Endoscopic Mucosal Resection of large sessile colonic polyps.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Large sessile polyp (equal to or greater than 20mm) * Intention to perform EMR * Aged 18 years or older

Exclusion criteria

* Colonic polyps less than 20mm * Aged younger then 18 years.

Design outcomes

Primary

Measure	Time frame	Description
Technical success for Endoscopic resection	6-60 months	To determine the safety, efficacy and predictors of success for Endoscopic Mucosal Resection of large sessile colorectal polyps. The utility of endoscopic criteria to stratify for the risk of Submucosal Invasive Cancer was also assessed.

Countries

Australia

Outcome results

None listed