Coronary Heart Disease
Conditions
Keywords
Computed tomography, Myocardial perfusion, Coronary heart disease
Brief summary
Recent advances in technology have resulted in the development of scanners that can image the heart blood vessels within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters. Further advances in technology allow the visualisation of both the blood vessels and the supply of blood to the heart muscle. Here we propose to assess the latest and most powerful computed tomography scanner and compare it to magnetic resonance and conventional coronary angiography.
Interventions
RADIATIONComputed tomography scan
Computed tomography will be performed using a 320 multidetector computed tomography scanner and may include coronary calcium score, coronary angiography and imaging of myocardial perfusion, function and viability.
Sponsors
NHS Lothian
University of Edinburgh
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* referred for invasive coronary angiography because of suspected coronary heart disease
Exclusion criteria
* inability or unwillingness to undergo computed tomography or magnetic resonance imaging * renal failure (serum creatinine \>200 micromol/L or estimated glomerular filtration rate \<30 mL/min) * hepatic failure * allergy to iodinated contrast or gadolinium * pregnancy * contraindication to adenosine infusion * inability to give informed consent * inability to perform fractional flow reserve during invasive coronary angiography
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial perfusion defects defined qualitatively by trained observers and quantitatively by computer software | 1 month | The primary outcome measure is to establish whether 320-multidetector computed tomography can identify myocardial perfusion defects as compared to the gold standards of 3Tesla magnetic resonance imaging and fractional flow reserve measured during invasive coronary angiography. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Identification of regional wall motion abnormalities qualitatively by trained observers | 1 month | Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging. |
| Identification of infarction qualitatively by trained observers | 1 month | Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging. |
| Identification of regional wall motion abnormalities quantitatively by computer software | 1 month | Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of regional wall motion abnormalities in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging. |
| Identification of infarction qualitatively by computer software | 1 month | Our secondary outcome measures are to assess the performance of 320-multidetector computed tomography in the detection of infarction in comparison to those obtained with 3Tesla cardiac magnetic resonance imaging. |
Countries
United Kingdom
Outcome results
None listed