Heart Failure
Conditions
Keywords
CRT, heart failure, CMR, safety
Brief summary
Cardiac MR (CMR) will be used to assess myocardial activation and hemodynamics in patients with CRT. Goals are to demonstrate that * differences in Left ventricle (LV)- right ventricle (RV) pacing delays cause differences in myocardial activation * differences in LV-RV pacing delays cause differences in LV/RV hemodynamics and to use these data to optimize CRT.
Detailed description
CMR will be performed in patients under CRT who are currently not responding to CRT. Different LV-RV delays will be programmed during CMR and LV function and different dyssynchrony parameters will be assessed. Results will be used to determine the optimal LV-RV delay, and CRT-devices will be reprogrammed accordingly. Improvement in NYHA-class/conversion to therapy responder will be determined clinically after 3 months.
Interventions
DEVICECRT reprogramming (Medtronic CRT)
CRT devices will be reprogrammed according to CMR analysis
Sponsors
University Hospital, Bonn
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* presence of CRT device * CRT non responder
Exclusion criteria
* pregnancy * end-stage renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| improvement in NYHA-class | 6 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| safety of CMR in CRT-patients | 6 months | pacing capture threshold, sensing and lead impedances will be monitored for significant and/or clinically relevant changes. |
Countries
Germany
Outcome results
None listed