Xanthohumol and Metabolic Syndrome

Inclusion criteria

* BMI 18-32 kg/m2 (to avoid confounders with extreme obesity). * Smoking or non-smoking. * Having normal or clinically acceptable physical examination and clinical laboratory tests. * Willing to abstain from beer consumption for four days prior to and during the study because beer contains XN and related prenylated (PN) flavonoids, such as IX, 8-PN and 6-PN. * Not currently taking prescription drugs. * Not having had acute medical conditions, such as hospitalizations or surgeries, at least three months prior to entry into the study. * If female, not pregnant (as confirmed by urine pregnancy test), breastfeeding, or planning to become pregnant before completing the study, and using effective method of contraception (hormonal methods NOT permitted). * If male with a partner of childbearing potential, willing to inform their partner of their participation in this clinical study and use highly effective methods of birth control during the study. * Not currently following an extreme diet, such as Atkin's, Zone or Ornish, and willing to maintain their current diet without extreme changes for the duration of the study.