French and EuRopean Outcome Registry in Intensive Care Unit

Conditions

Intensive Care Unit Syndrome, Tracheal Intubation Morbidity

Keywords

BIOLOGICAL MARKERS, INTENSIVE CARE UNIT, MORTALITY, QUALITY OF LIFE, CARDIOVASCULAR

Brief summary

The purpose of this study is to identify within a cohort of ICU patients admitted for severe illness those who are at risk of death in the year following the discharge from ICU.

Detailed description

FROG-ICU is an epidemiological, observational, prospective, multi centric, cohort study designed for description, prognostic and evaluation. This trial includes as a first step a complete registry of patients admitted to the ICU and as a second step, the outcome of the patients at 1 year after they have been discharged alive from ICU. Plasma and urine samples will be with drawn biomarkers measurements at admission and ICU discharge. It is a multicentric study involving 1 center in Belgium et 24 centers in France.

Blet A, Walter-Petrich A, Chérifa M, Bruno J, Tran Dinh A, Azoulay E, Chousterman B, Cotter G, Davison B, Deniau B, Gayat E, Guidet B, Harrois A, Kimmoun A, Leone M, Wittebole X, Ambrosy AP, Mebazaa A, Resche-Rigon M.

2025-12-10

10.1016/j.jcrc.2025.155401

Association between serum uric acid level and outcome in intensive care unit, an ancillary analysis of the FROG-ICU cohort (URIC-ICU)

Antoine Borouchaki, Charles de Roquetaillade, Louis Boutin, Étienne Gayat, Alexandre Mebazaa et al. (6 authors)

Anaesthesia Critical Care & Pain Medicine2025-10-01

10.1016/j.accpm.2025.101610

Identifying biomarker-driven subphenotypes of cardiogenic shock: analysis of prospective cohorts and randomized controlled trials.

Soussi S, Tarvasmäki T, Kimmoun A, Ahmadiankalati M, Azibani F, Dos Santos CC, Duarte K, Gayat E, Jentzer JC, Harjola VP, Hibbert B, Jung C, Johan L, Levy B, Lu Z, Lawler PR, Marshall JC, Pöss J, Sadoune M, Nguyen A, Raynor A, Peoc'h K, Thiele H, Mathew R, Mebazaa A.

2024-12-1813 citations

10.1016/j.eclinm.2024.103013

Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Alice Blet, J. Brennan McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti et al. (23 authors)

Critical Care2022-10-0734 citations

10.1186/s13054-022-04171-1

Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort.

Soussi S, Sharma D, Jüni P, Lebovic G, Brochard L, Marshall JC, Lawler PR, Herridge M, Ferguson N, Del Sorbo L, Feliot E, Mebazaa A, Acton E, Kennedy JN, Xu W, Gayat E, Dos Santos CC, FROG-ICU, CCCTBG trans-trial group study for InFACT - the International Forum for Acute Care Trialists.

2022-04-2132 citations

10.1186/s13054-022-03972-8

Early echocardiography by treating physicians and outcome in the critically ill: An ancillary study from the prospective multicenter trial FROG-ICU.

Takagi K, Akiyama E, Paternot A, Miró Ò, Charron C, Gayat E, Deye N, Cariou A, Monnet X, Jaber S, Guidet B, Damoisel C, Barthélémy R, Azoulay E, Kimmoun A, Fournier MC, Cholley B, Edwards C, Davison BA, Cotter G, Vieillard-Baron A, Mebazaa A.

2022-03-093 citations

10.1016/j.jcrc.2022.154013

Elevated plasma Galectin-3 is associated with major adverse kidney events and death after ICU admission.

Boutin L, Legrand M, Sadoune M, Mebazaa A, Gayat E, Chadjichristos CE, Dépret F.

2022-01-0618 citations

10.1186/s13054-021-03878-x

One-year outcome of patients admitted after cardiac arrest compared to other causes of ICU admission. An ancillary analysis of the observational prospective and multicentric FROG-ICU study.

Kimmoun A, Cariou A, Gayat E, Feliot E, Takagi K, Megarbane B, Mebazaa A, Deye N, FROG-ICU Study investigators.

2019-10-312 citations

10.1016/j.resuscitation.2019.10.021

Tracheostomy and long-term mortality in ICU patients undergoing prolonged mechanical ventilation

Raphaël Cinotti, Sébastian Voicu, Samir Jaber, Benjamin G. Chousterman, Cathérine Paugam‐Burtz et al. (13 authors)

PLoS ONE2019-10-0229 citations

10.1371/journal.pone.0220399

P3506A novel urinary biomarker predicts 1 year mortality after discharge from Intensive Care

Z Y Zhang, Esther Nkuipou‐Kenfack, Weili Yang, Blerim Mujaj, Lutgarde Thijs et al. (9 authors)

European Heart Journal2019-10-011 citations

10.1093/eurheartj/ehz745.0370

Gender and survival of critically ill patients: results from the FROG-ICU study.

Hollinger A, Gayat E, Féliot E, Paugam-Burtz C, Fournier MC, Duranteau J, Lefrant JY, Leone M, Jaber S, Mebazaa A, Arrigo M, FROG ICU study investigators.

2019-03-2929 citations

10.1186/s13613-019-0514-y

Association of social deprivation with 1-year outcome of ICU survivors: results from the FROG-ICU study.

Bastian K, Hollinger A, Mebazaa A, Azoulay E, Féliot E, Chevreul K, Fournier MC, Guidet B, Michel M, Montravers P, Pili-Floury S, Sonneville R, Siegemund M, Gayat E, FROG-ICU Study Investigators.

2018-10-2335 citations

10.1007/s00134-018-5412-5

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study.

Hollinger A, Wittebole X, François B, Pickkers P, Antonelli M, Gayat E, Chousterman BG, Lascarrou JB, Dugernier T, Di Somma S, Struck J, Bergmann A, Beishuizen A, Constantin JM, Damoisel C, Deye N, Gaudry S, Huberlant V, Marx G, Mercier E, Oueslati H, Hartmann O, Sonneville R, Laterre PF, Mebazaa A, Legrand M.

2018-08-2277 citations

10.1016/j.ekir.2018.08.006

Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury.

Gayat E, Hollinger A, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Chousterman BG, Lu Q, Laterre PF, Monnet X, Darmon M, Leone M, Guidet B, Sonneville R, Lefrant JY, Fournier MC, Resche-Rigon M, Mebazaa A, Legrand M, FROG-ICU investigators.

2018-05-1574 citations

10.1007/s00134-018-5160-6

Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study.

Gayat E, Cariou A, Deye N, Vieillard-Baron A, Jaber S, Damoisel C, Lu Q, Monnet X, Rennuit I, Azoulay E, Léone M, Oueslati H, Guidet B, Friedman D, Tesnière A, Sonneville R, Montravers P, Pili-Floury S, Lefrant JY, Duranteau J, Laterre PF, Brechot N, Chevreul K, Michel M, Cholley B, Legrand M, Launay JM, Vicaut E, Singer M, Resche-Rigon M, Mebazaa A.

2018-01-18125 citations

10.1186/s13054-017-1922-8

Post-ICU discharge and outcome: rationale and methods of the The French and euRopean Outcome reGistry in Intensive Care Units (FROG-ICU) observational study.

Mebazaa A, Casadio MC, Azoulay E, Guidet B, Jaber S, Levy B, Payen D, Vicaut E, Resche-Rigon M, Gayat E.

2015-10-1232 citations

10.1186/s12871-015-0129-2

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Adult patients hospitalized in ICU * Patients should have been intubated more than 24 hours * or treated with a positive inotropic agent for more than 24 hours (if not ventilated

Exclusion criteria

* age \< 18 years * pregnancy women * Breast-feeding women * Not affiliated with social security * Dying man * End of life patient * Traumatic Brain Injury (IGCS \< 8) * NTBR * vegetative coma * Transplanted for less than year * no french speaking patient * out of france resident * end of life decision during the following

Design outcomes

Primary

Measure	Time frame
All cause mortality at one year after ICU discharge	one year

Secondary

Measure	Time frame
To assess quality of life in the year following a stay in ICU	one year
To identify key determinants of cardiovascular morbidity and mortality in the year following a stay in ICU	one year
To investigate the performance of plasma biomarkers usually measured in ICU, to assess the risk of death during the stay in ICU and one year after the discharge.	one year
To set up a biological collection of plasma and urine, in order to measure new plasma biomarkers in the assessment of prognosis in the year following a stay in ICU.	one year
to evaluate social conditions	one year

Countries

France

Outcome results