Macronutrients and Gut Hormone Secretion

Effects of Macronutrients on Gut Hormone and Islet Hormone Secretion in Healthy Volunteers and Type 2 Diabetes

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01366794

Enrollment

Registered

2011-06-06

Start date

2011-09-30

Completion date

2013-09-30

Last updated

2014-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes

Keywords

Gut hormones, Insulin secretion

Brief summary

Study hypothesis is to examine the relative contribution of macronutrients for gut hormone secretion after a mixed meal in healthy volunteers and in subjects with type 2 diabetes. Individual macronutrients or a mixed meal will therefore be served and gut hormones are measured during the following 300 min.

Detailed description

In healthy volunteers and subjects with dietary regulated diabetes mellitus, glucose, protein mixture or fat emulsion will be served individually and on a separate occasions a mixed meal will be served. Samples will be taken during the following 300 min. Concentrations of the gut hormones glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, insulin and glucagon will be determined.

Interventions

OTHERMacronutrients

Glucose 330 kcal Protein 110 kcal Fat emulsion 110 kcal Mixed meal 550 kcal

Study design

Allocation

NON_RANDOMIZED

Intervention model

FACTORIAL

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

35 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy status or type 2 diabetes with dietary regulation

Exclusion criteria

* Liver disease * kidney disease * thyroid disease

Design outcomes

Primary

Measure	Time frame
Release of gut hormones	300 min

Secondary

Measure	Time frame
Insulin secretion	300 min

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026