Gut Hormones After Meal Ingestion in Males Versus Females

Effects of Varying Meal Size on Gut Hormone and Islet Hormone Secretion in Males Versus Females

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01366781

Enrollment

Registered

2011-06-06

Start date

2011-05-31

Completion date

2014-06-30

Last updated

2014-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Normal Non-fluency

Keywords

Gut hormones, Insulin secretion

Brief summary

The study hypothesis is that the release of gut hormones is increased proportionally to caloric load in each meal. Three different meals with different meal size will therefore be served and gut hormones determined.

Detailed description

In healthy males and females, meals with 511, 743 and 1034 kcal will be given orally. Samples will be taken during the following 300 min and gut hormones (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1) will be determined along with insulin and glucagon levels.

Interventions

OTHERMeal ingestion

Meal 511 kcal, meal 743 kcal or meal 1034 kcal

Study design

Allocation

NON_RANDOMIZED

Intervention model

FACTORIAL

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy status

Exclusion criteria

* Diabetes * Liver disease * kidney disease * thyroid disease

Design outcomes

Primary

Measure	Time frame
Release of gut hormones	300 min

Secondary

Measure	Time frame
Insulin secretion	300 min

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026