Normal Non-fluency
Conditions
Keywords
Gut hormones, Insulin secretion, Normal physiology
Brief summary
The study hypothesis is that gut hormones are released after oral but not intravenous amino acids which result in stimulation of insulin secretion.
Detailed description
Amino acid mixture is given orally or intravenously to match total concentrations of amino acids in healthy subjects. Samples are taken regularly for 300 min after administrations. Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and glucagon.
Interventions
OTHEROral amino acid mixture
Amino acid mixture 2,93 ml/kg
OTHERIntravenous amino acid administration
Amino acid mixture 2,93 ml/kg
Sponsors
Lund University
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
20 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjects
Exclusion criteria
* Diabetes * Liver disease * Kidney disease * Thyroid disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut hormone secretion | 300 min |
Secondary
| Measure | Time frame |
|---|---|
| Insulin secretion | 300 min |
Countries
Sweden
Outcome results
None listed