Gastric Cancer
Conditions
Brief summary
The study aims to: 1. Achieve molecular imaging of MG7 antigen in patients with gastric cancer in vivo using confocal laser endomicroscopy. 2. Compare the results of in vivo MG7-specific molecular imaging with CLE and ex vivo immunohistochemistry .
Detailed description
Gastric cancer remains the world's second leading cause of cancer-related death. Improved prognosis essentially depend on earlier diagnosis. Gastric monoclonal antibody MG7 has been validated as a specific antibody in gastric cancerous tissue. Conventional evaluation of MG7 antigen expression is immunohistochemistry, which is time-consuming, and the immunoreactivity can be affected by storage and fixation of tissue. Confocal laser endomicrosopy enables visualization of the cellular and subcellular structures in vivo. Thus this study aims to achieve molecular imaging of MG7 antigen in gastric cancer in vivo using confocal laser endomicroscopy.
Interventions
None listed
Sponsors
Shandong University
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* patients with endoscopically diagnosed gastric cancer
Exclusion criteria
* Patients who are allergic to fluorescein sodium * Patients who are unwilling to sign or give the informed consent form * Patients with giant tumors or obvious GI tract bleeding which make it hard or impossible to observe the lesions * Patients with impaired cardiac, liver or renal function * Patients with coagulopathy * Patients with pregnancy or breastfeeding
Countries
China
Outcome results
None listed