Study of the Natural History of FFR Guided Percutaneous Coronary Intervention

Conditions

Coronary Artery Disease

Keywords

FFR

Brief summary

About 20,000 patients with FFR (Fractional Flow Reserve) will be enrolled and evaluated for the natural history of coronary lesions at 2 years clinical and imaging follow-up.

Detailed description

This is a multicenter, prospective cohort. About 20,000 patients with FFR will be enrolled at multi centres in Korea.

Jung‐Min Ahn, Duk-Woo Park, Seon‐Ok Kim, Do‐Yoon Kang, Cheol-Hyun Lee et al. (9 authors)

Circulation Cardiovascular Interventions2020-04-297 citations

10.1161/circinterventions.118.007868

Impact of Coronary Lesion Geometry on Fractional Flow Reserve

Do‐Yoon Kang, Jung‐Min Ahn, Young‐Woo Kim, Ji Young Moon, Joon Sang Lee et al. (13 authors)

Circulation Cardiovascular Imaging2018-06-0133 citations

10.1161/circimaging.117.007087

Deferred vs. performed revascularization for coronary stenosis with grey-zone fractional flow reserve values: data from the IRIS-FFR registry

Do‐Yoon Kang, Jung‐Min Ahn, Cheol Hyun Lee, Pil Hyung Lee, Duk‐Woo Park et al. (13 authors)

European Heart Journal2018-01-3145 citations

10.1093/eurheartj/ehy079

Lee JM, Park J, Hwang D, Kim CH, Choi KH, Rhee TM, Tong Y, Park JJ, Shin ES, Nam CW, Doh JH, Koo BK.

2017-10-0140 citations

10.1016/j.jacc.2017.09.007

Exploring Coronary Circulatory Response to Stenosis and Its Association With Invasive Physiologic Indexes Using Absolute Myocardial Blood Flow and Coronary Pressure

Joo Myung Lee, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Yaliang Tong et al. (11 authors)

Circulation2017-08-3042 citations

10.1161/circulationaha.117.029911

Fractional Flow Reserve and Cardiac Events in Coronary Artery Disease

Jung‐Min Ahn, Duk‐Woo Park, Eun‐Seok Shin, Bon‐Kwon Koo, Chang‐Wook Nam et al. (26 authors)

Circulation2017-03-29176 citations

10.1161/circulationaha.116.024433

Integrated Myocardial Perfusion Imaging Diagnostics Improve Detection of Functionally Significant Coronary Artery Stenosis by <sup>13</sup> N-ammonia Positron Emission Tomography

Joo Myung Lee, Chee Hae Kim, Bon‐Kwon Koo, Doyeon Hwang, Jonghanne Park et al. (16 authors)

Circulation Cardiovascular Imaging2016-09-0175 citations

10.1161/circimaging.116.004768

Sex differences in the visual-functional mismatch between coronary angiography or intravascular ultrasound versus fractional flow reserve.

Kang SJ, Ahn JM, Han S, Lee JY, Kim WJ, Park DW, Lee SW, Kim YH, Lee CW, Park SW, Mintz GS, Park SJ.

2013-06-0157 citations

10.1016/j.jcin.2013.02.016

Visual-functional mismatch between coronary angiography and fractional flow reserve.

Park SJ, Kang SJ, Ahn JM, Shim EB, Kim YT, Yun SC, Song H, Lee JY, Kim WJ, Park DW, Lee SW, Kim YH, Lee CW, Mintz GS, Park SW.

2012-10-01238 citations

10.1016/j.jcin.2012.07.007

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

35 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Age 35 years and older * FFR measurement on one and more coronary artery stenosis * Willing and able to provide informed, written consent

Exclusion criteria

* Stenosis with TIMI\<3 flow * Graft vessel * Ejection fraction \< 30% * Angiographic evidence of extreme tortuosity or calcified coronary vessels * Suspected coronary spasm even after sufficient nitrate injected * Life expectancy \<2 year * Planned cardiac surgery or planned major non cardiac surgery * Woman who are breastfeeding, pregnant or planning to become pregnant during the course of the study Imaging study specific

Design outcomes

Primary

Measure	Time frame
Target vessel failure	2 year after index FFR measurement
composite Cardiac Death,Non Fatal Myocardial Infarction, Target Vessel Revascularization, and Indeterminate events	at 2 year after index FFR measurement

Secondary

Measure	Time frame
Death (all cause and cardiac)	at 2 year after index FFR measurement
MI	at 2 year after index FFR measurement
Target vessel revascularization	at 2 year after index FFR measurement
Target lesion revascularization	at 2 year after index FFR measurement
Any re-hospitalization with a cardiac cause	2 year follow-up after index FFR measurement
cardiac death and myocardial infarction	2 year follow-up after index FFR measurement
stented lesion related event including death, myocardial infarction, repeat revascularization	2 year follow-up after index FFR measurement
stroke	2 year follow-up after index FFR measurement
stent thrombosis	2 year follow-up after index FFR measurement
anginal status	2 year follow-up after index FFR measurement
number of anti-anginal medication prescribed	2 year follow-up after index FFR measurement
complication of FFR measurement	2 year follow-up after index FFR measurement
clinical predictors of events	2 year follow-up after index FFR measurement
change in plaque composition (%necrotic core volume) in target segment	2 year follow-up after index FFR measurement
change in plaque type assessed by VH(Virtual Histology) and OCT(Optical coherence tomography)	2 year follow-up after index FFR measurement
change in total atheroma volume and percent atheroma volume	2 year follow-up after index FFR measurement
change in IVUS-measured MLA	2 year follow-up after index FFR measurement
change in FFR	2 year follow-up after index FFR measurement

Countries

South Korea

Contacts

CONTACTSeung-Jung Park, MD, PhD

sjpark@amc.seoul.kr

CONTACTJung-min Ahn, MD

drjmahn@gmail.com

PRINCIPAL_INVESTIGATORSeung-Jung Park, MD,PhD

Asan Medical Center

Outcome results