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Biomarker in Tissue Samples From Patients With Ewing Sarcoma

INI-1 Deletions in Ewing Sarcoma

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT01365949
Enrollment
40
Registered
2011-06-03
Start date
2011-05-31
Completion date
Unknown
Last updated
2016-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sarcoma

Keywords

Ewing sarcoma/peripheral primitive neuroectodermal tumor (PNET)

Brief summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in tissue samples from patients with Ewing sarcoma.

Detailed description

OBJECTIVES: * To determine the frequency of INI-1 protein loss in Ewing Sarcoma. OUTLINE: Previously collected tissue samples are analyzed for INI-1 protein loss by IHC and tissue microarray.

Interventions

GENETICmicroarray analysis
GENETICprotein analysis
OTHERimmunohistochemistry staining method
OTHERlaboratory biomarker analysis

Sponsors

National Cancer Institute (NCI)
CollaboratorNIH
Children's Oncology Group
Lead SponsorNETWORK

Study design

Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
No minimum to 120 Years
Healthy volunteers
No

Inclusion criteria

DISEASE CHARACTERISTICS: * Diagnosis of Ewing sarcoma * Prepared tissue microarray with Ewing sarcoma samples available PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Design outcomes

Primary

MeasureTime frame
Frequency of INI1 protein loss in Ewing Sarcoma—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026