Hypertension
Conditions
Keywords
Hypertension
Brief summary
Prevalence rates of hypertension and diabetes are high in Taiwan. Little attention is given to evidence-based dietary therapy in Taiwan. Patients, after confirmed diagnosis, are mostly prescribed with medications without comprehensive instructions on dietary therapy. DASH diet has been proven to be an effective dietary approach to reduce blood pressure for hypertension patients in US. However, dietary difference and patient profiles across countries are evident. In addition, hypertensive patients are often combined with hyperglycemia. Carbohydrate burden of DASH diet may be higher than most dietitians desire. Therefore, the investigators in tend to design a Taiwanese DASH diet and a lower carbohydrate DASH diet and test their efficacy on both blood pressure and fasting glucose lowering.
Interventions
OTHERDASH diet
DASH diet: A diet rich in whole grain, fruit and vegetable, low-fat dairy products, white meat and nuts; and lower of total fat and saturated fat.
OTHERlower carbohydrate DASH diet
lower carbohydrate DASH diet: A DASH diet with lower carbohydrate percentage
Sponsors
Taipei Veterans General Hospital, Taiwan
National Health Research Institutes, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 20-65 years, weight 50-80 kg(±5kg) * Two blood pressure readings and fasting blood glucose measurements: 1. fasting blood glucose of 100-125 ml/dL and not using antidiabetic medication. 2. systolic blood pressure of 130-159 mmHg or diastolic blood pressure of 85-99 mmHg and not using antihypertensive medication.
Exclusion criteria
* (a) taking blood glucose lowering, antihypertensive or oral steroid medications. (b) history of stroke, cardiovascular disease, abnormal liver function, cancer, stomach ulcer, inflammatory bowel disease or other chronic diseases that will influence the diet of participants. (c) Major surgery in the past year or about to undergo major surgery. (d) Is the holder of a major illness card. (e) Takes antipsychotics. (f) Harmful drinker (more than 14 drinks per week) (g) Has food allergies or food intolerance. (h) Pregnant or breastfeeding. (i) Unwilling to cease intake of vitamin or mineral supplements or antacids containing magnesium or calcium for the duration of the study. (j) Other medications or physiological states influencing the absorption of nutrients. (k) Other individuals deemed unsuitable to participate in the intervention by their treating physician.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure | 4 weeks | Baseline and per week after intervention |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose, fasting insulin, cholesterol, triglycerides, HDL-C and LDL-C | will be measured at 0, 2, 4, 8, 10 and 12 weeks |
| Urinary magnesium, potassium, sodium and creatinine | will be measured at 0, 2, 4, 8, 10 and 12 weeks |
Countries
Taiwan
Outcome results
None listed