Local Infiltration With Bupivacaine to Increase Quality of Post-operative Pain Control in Total Knee Replacement

Periarticular Injection With Bupivacaine For Post-Operative Pain Control In Total Knee Replacement: A Prospective Randomized Double-Blind Controlled Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01364194

Enrollment

Registered

2011-06-02

Start date

2010-03-31

Completion date

2010-09-30

Last updated

2011-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative, Arthropathy of Knee Joint

Keywords

Post operative pain, Total knee replacement, Total knee arthroplasty, Bupivacaine, Periarticular injection, Placebo, Morphine consumption

Brief summary

The purpose of this study is to evaluate the efficacy of periarticular injection with 0.25% bupivacaine for controlling pain after total knee replacement to improve the quality of post-operative care.

Detailed description

Compare post operative pain control after total knee replacement by periarticular injection with 0.25% bupivacaine compare with 0.9% normal saline.

Interventions

DRUG0.25% Bupivacaine

Periarticular injection with 20 ml of 0.25% bupivacaine before wound closure.

DRUG0.9% normal saline

Periarticular injection with 20 ml of 0.9% normal saline before wound closure.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 80 Years

Healthy volunteers

Inclusion criteria

* primary osteoarthritis patients undergoing total knee replacement at Siriraj Hospital * BMI between 20-35 * having a full understanding of the question in this trial

Exclusion criteria

* allergy to NSAIDs, Acetaminophen, Bupivacaine * blood creatinine more than 1.5 mg/dl or creatinine clearance less than 60 mL/min * abnormal liver function * previous surgery on the knee undergoing total knee replacement * patient could not receive spinal anesthesia

Design outcomes

Primary

Measure	Time frame	Description
Post operative pain	96 hour post operation	Measure by Visual analog scale scores and morphine consumption

Secondary

Measure	Time frame	Description
Complication of Morphine consumption	96 hour post operation	nausea, pruritis, urinary retention and constipation

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026