Obesity, Type 2 Diabetes
Conditions
Keywords
Insulin resistance, Inflammation, Hypoxia
Brief summary
Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have preliminary evidence showing that hyperbaric oxygen therapy rapidly increases insulin sensitivity in humans. This requires confirmation in a larger population, and with this study the investigators will also test for mechanisms how this occurs. The investigators suspect that modulation of hypoxia and stress response proteins following changes in tissue oxygenation may contribute to these improvements. This study has the potential to yield new and important insights into the insulin resistance in obesity.
Interventions
PROCEDUREHyperbaric Oxygen Treatment
Participants will undergo 4 treatments of hyperbaric oxygen. Each treatment consists of 90 minutes compression at 2 atmospheres of pressure, with 30 minutes decompression back to 1 atmosphere, during this time, patients will be treated with 100% Oxygen delivered via a hood system.
Sponsors
University of Adelaide
Study design
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
45 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Obese men with and without type 2 diabetes aged 45-70 * Lean men without type 2 diabetes aged 45-70
Exclusion criteria
* smokers * claustrophobic * sleep apnoea * blood donor * exercise more than 2 times per week * under certain medications eg: bleomycin,corticosteroid
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity | 1 year | Using Hyperinsulinemic clamp |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hypoxia and inflammatory markers | 1 year | using IHC, qPCR, Western blot |
Countries
Australia
Outcome results
None listed