Cytomegalovirus Endotheliitis
Conditions
Keywords
cytomegalovirus endotheliitis
Brief summary
The purpose of this study was to evaluate the outcomes of topical ganciclovir in patients with cytomegalovirus endotheliitis receiving penetrating keratoplasty at National Taiwan University hospital.
Detailed description
In this study, we recruit 7 immunocompetent patients with unexplained graft failures, which mimicked herpetic anterior uveitis and graft rejection initially, were diagnosed as CMV endotheliitis after aqueous tapping for CMV polymerase chain reaction (PCR). Topical ganciclovir was used to control and prevent the reactivation of CMV without systemic application and their clinical courses were presented after this treatment modality. The purpose of this study was to evaluate the outcomes of topical ganciclovir in patients with cytomegalovirus endotheliitis receiving penetrating keratoplasty at National Taiwan University hospital.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* immunocompetent patients with positive results of the CMV PCR (polymerase chain reaction) from aqueous humor tapping receiving penetrating keratoplasty
Exclusion criteria
* patients receiving systemic or intravitreal ganciclovir before topical ganciclovir use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| clinical courses before and after topical ganciclovir in patients with CMV endotheliitis | participants will be monitored after receiving topical ganciclovir,an expected average of 1 year | evaluations including aqueous PCR for CMV, endothelium cell density on confocal microscopy,degree of anterior chamber inflammation.. |
Countries
Taiwan
Contacts
Primary ContactI-Jong Wang, M.D. PhD
Outcome results
None listed