Huntington Disease
Conditions
Keywords
Energy, Metabolism, Spectroscopy
Brief summary
The purpose of this study is to identify and quantify a brain energy deficit in Huntington patients, using 31P-RMN spectroscopy.
Interventions
OTHER31P-MR spectroscopy
Brain energy deficit is quantified using 31P-MR spectroscopy
OTHER31P-RMN spectroscopy
Brain energy deficit is quantified using 31P-RMN spectroscopy
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 5\<UHDRS\<50 * Age\>18 years * Ability to undergo MR scanning * Covered by french social security
Exclusion criteria
* Evidence of psychiatric disorder * Attendant neurological disorder * Contraindications to MRI (claustrophobia, metallic or material implants) * Severe head injury * Unable to understand the protocol * Pregnancy * Failure to give informed consent * Subjects with
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain energy deficit in Huntington patients | one year | 31P-MRS allows quantification of high-energy phosphate metabolites such as ATP and phosphocreatine. Objective: to look at brain energy metabolism during rest and activation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlating a brain energy deficit with (i) biochemical parameters and (ii) clinical parameters in Huntington patients | one year | Biochemical parameters include metabolites that we previously showed to be biomarkers in HD: branched chain amino acids and IGF1. Clinical parameters include UHDRS and TFC. |
Countries
France
Outcome results
None listed