Metformin Treatment, Renal Function and Lactic Acidosis

Metformin Treatment, Renal Function and Lactic Acidosis. A Population Based

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01358994

Enrollment

4500

Registered

2011-05-24

Start date

2011-01-31

Completion date

2011-04-30

Last updated

2018-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Mellitus

Keywords

metformin, type 2 diabetes, e-GFR, creatinine, lactic acidosis

Brief summary

From a central registry at the National Board of Health and Welfare in Sweden collect all patients in the city of Malmö prescribed metformin during two years. Glomerular filtration rate (eGFR) was estimated from the CKD-EPI formula (n=5408) and compared to a control material (n=2815) from the same town. All cases of severe lactic acidosis rendering ICU admission were also sought. The study hypothesis is that metformin is prescribed to patients with lower GFR than anticipated with very few cases of lactic acidosis registered.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* Patients in the city of Malmö prescribed metformin at least three times during two years * Available at least one p-creatinine during the two years

Countries

Sweden

Outcome results