Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities

Periodontal-, Cardiovascular- and Aneurysmal Diseases.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01358630

Enrollment

100

Registered

2011-05-24

Start date

2008-10-31

Completion date

2015-10-31

Last updated

2011-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis, Vascular Disease

Keywords

Periodontitis, Vascular disease, Proinflammatory cytokines

Brief summary

The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis,

Exclusion criteria

* patients whom undergone antibiotic treatment the past month. * patients whom undergone periodontal treatment the past 6 months. * patients with no teeth

Countries

Norway

Contacts

Primary ContactIngar Olsen, Prof.PhD.

ingar.olsen@odont.uio.no+47-22840350

Backup ContactJørgen J Jørgensen, Prof.PhD

j.j.jorgensen@medisin.uio.no+47-22894496

Outcome results