Sarcopenia
Conditions
Keywords
sarcopenia, aging, rehabilitation, exercise
Brief summary
The purpose of this study is to determine the benefits of negative work progressive resistance exercise (PRE) for the conservative management of sarcopenia in older male Veterans at the DC VAMC. Efficacy will be assessed by examining post-exercise changes in metabolic and inflammatory markers, muscle morphology, strength, and functional status.
Detailed description
The chief aim of this protocol is to determine the efficacy of negative work progressive resistance exercise (PRE) in the management of sarcopenia in older male Veterans at the DC VAMC. This proposed study is a randomized clinical trial using a single-arm, delayed cross-over design with repeated measures. This method is a patient-first approach to clinical research that permits all participants to receive the intervention while allowing the investigators to conduct both within subjects and between subjects comparisons with a modest study enrollment. During the pre-treatment period we will recruit, screen, and consent 30 older men with sarcopenia. The participants will be randomized into two groups: active treatment and delayed treatment. The initial active treatment and delayed treatment periods will last 12 weeks. After 12 weeks, the participants in the delayed treatment group will crossover (without a washout period) and start 12 weeks of intervention. All participants will detrain and be monitored for follow up during their respective 12-week post treatment period. Outcome measures include post-exercise changes in metabolic and inflammatory markers, muscle morphology, strength, and functional status.
Interventions
BEHAVIORALNegative work exercise
Submaximal negative work exercise using an isokinetic dynamometer will be performed twice per week for 12 weeks. Exercise volume will be 3 sets of 10 repetitions for the knee and shoulder extensors.
Sponsors
US Department of Veterans Affairs
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
60 Years to 79 Years
Healthy volunteers
Yes
Inclusion criteria
Adult, ambulatory males \> 60 years old (n=30) will be recruited for this proposed study. Participant inclusion criteria also includes having clinically significant sarcopenia based on the body composition assessment showing an aLM that is \< 2 SD below the mean values of a young adult reference group using DEXA scanning.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in insulin sensitivity following the exercise intervention as estimated with the QUICKI algorithm (quantitative insulin sensitivity check index) | Change from baseline in QUICKI values at week 6, week 12, and week 24 | Blood tests will be obtained after a 12- hour overnight fast at baseline, weeks 6, week 12 and week 24: glucose and insulin values will be determined before and during a standard (75 g) 2 hour oral glucose tolerance test (to determine insulin sensitivity via QUICKI algorithm. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Peak isokinetic torque | Treatment weeks: 1, 6, and 12; post-treatment weeks: 6 and 12 | Isokinetic knee and shoulder extension torques will be obtained bilaterally using the Biodex System 3 |
| Diagnostic ultrasongraphy | Treatment weeks: 1, 6, and 12; post-treatment weeks: 6 and 12 | Muscle thickness, pennation angle, and area at the flexor digitorum superficialis, lower-trapezius, rectus femoris and tibialis anterior (dominant side only). |
Countries
United States
Outcome results
None listed