Seed Movement in Prostate Brachytherapy Implants: Clinical Measurement and Dosimetric Consequences

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01355185

Enrollment

Registered

2011-05-18

Start date

2011-08-31

Completion date

2015-06-30

Last updated

2014-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate Cancer

Keywords

Seed movement, implants, prostate brachytherapy, localized

Brief summary

There are substantial uncertainties with contemporary seed placement techniques in prostate brachytherapy, particularly with the impact of seed movement after an implant due to edema and migration of seeds in the prostate and peri-prostatic tissues. This study will accrue 20 patients undergoing prostate brachytherapy implants and perform serial CT and MRI scans at specified intervals (pre-operatively, day 0, day 3, day 10 and day 28) to characterize these phenomena.

Detailed description

Prostate brachytherapy is an effective treatment option for men with localized prostate cancer with excellent cure rates and a favorable toxicity profile. Having a more detailed understanding of seed movement after an implant will provide clinicians with details about the clinical impact of these phenomena on implants and provide the detailed understanding of these phenomena that are necessary for more sophisticated brachytherapy implants that are envisioned in the future.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* treated with prostate brachytherapy * low risk or intermediate risk prostate cancer * ambulatory * stable medical condition * 18 years of age or older * capable of informed consent

Exclusion criteria

* no use of any hormonal therapy * unable to have MRI scans (ie. presence of metallic foreign object, aneurysm clip, cardiac pacemaker, internal wires, implanted pump, implanted cardiac device, claustrophobia, etc.

Countries

Canada

Contacts

Primary ContactNawaid Usmani, MD, FRCPC

Nawaid.Usmani@albertahealthservices.ca780-432-8518

Backup ContactRonald Sloboda, PhD

Ron.Sloboda@albertahealthservices.ca780-432-8719

Outcome results