Hypertension
Conditions
Brief summary
Primary hypothesis: Catheter-based renal denervation reduces central sympathetic activation in patients with refractory hypertension. Secondary hypotheses: 1. The magnitude of the individual depressor response after catheter-based renal denervation depends on the extent of sympathoinhibition. 2. Both, the reduction in arterial pressure and in central sympathetic activation are sustained over time up to 24±3 months after catheter-based renal denervation. 3. Catheter-based renal denervation resets the sympathetic baroreflex to lower blood pressure values.
Interventions
None listed
Sponsors
Hannover Medical School
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Refractory hypertension (as defined by the WHO: poorly controlled hypertension (\>140/90 mmHg) despite adequate doses of at least three antihypertensive drugs including a diuretic) * Men or women aged \>18 years * Intact peroneal nerve * Written informed consent
Exclusion criteria
* Diseases, dysfunctions, or medications (such as NET inhibitors) that exclude a participation in the study according to the investigator. * Legal incompetence or circumstances that interfere with the patient´s ability to fully understand scope, relevance, and/or consequences of participation in this study. * People in custody * hypersensitivity to clonidine, phenylephrine, or nitroprusside-sodium * sick sinus syndrome, second or third degree AV block, bradycardia \< 50 bpm (contraindication for clonidine) * endogenous depression (contraindication for clonidine)
Countries
Germany
Contacts
Primary ContactHeusser Karsten, MD
Backup ContactReuter Julia, MD
Outcome results
None listed