Influence of Extracorporeal Circulation on Platelet Function of Patients Undergoing Cardiac Surgery

Influence of Extracorporeal Circulation on Platelet Function of Patients Undergoing Cardiac Surgery - a Prospective Observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01354847

Enrollment

Registered

2011-05-17

Start date

2011-06-30

Completion date

2013-10-31

Last updated

2013-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acquired Platelet Function Disorder

Keywords

extracorporeal circulation, platelet dysfunction, Multiplate electrode aggregometry analyses, Multiplate

Brief summary

This study is planned to investigate the relationship between duration of extracorporeal circulation and the extent of (acquired) platelet dysfunctions in patients undergoing cardiac surgery.

Detailed description

Patients undergoing complex cardiac surgery are planned to be included. At several intra- and postoperative measuring point, blood is drawn for multiple electrode aggregometry to investigate ex-vivo platelet aggregation as a surrogate for platelet function. Transfusion rate of allogenic blood products as well as postoperative blood loss is planned to be recorded.

Interventions

DEVICEMultiple electrode aggregometry analyses (Multiple Electrode Aggregometry, Multiplate(R), Verum Diagnostica, Munich, Germany)

ex vivo platelet aggregation at several intraoperative and postoperative measuring points.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* duration of extracorporeal circulation \> 120 min

Exclusion criteria

* pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Changes in arachidonic acid induced platelet aggregation as compared to baseline (before extracorporeal circulation)	Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU	Multiple Electrode aggregometry parameters

Secondary

Measure	Time frame	Description
Changes in Adenosin Diphosphate (ADP) and Thrombin induced platelet aggregation as compared to baseline (before extracorporeal circulation)	Baseline (before extracorporeal circulation) and 60, 90, 120, 150 and 180 minutes after extracorporal circulation as well as ad admission to ICU	Multiple electrode aggregometry analyses

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026