Atopy, Metabolic Syndrome, Preterm Delivery
Conditions
Keywords
Fish oil, Pregnancy, RCT, Birth weight, Gestational age, Asthma and allergies, Metabolic syndrome, Obesity
Brief summary
The aim of the trial is to investigate the effect of daily supplementation with 2.7 grams of long chain n-3 fatty acids during the third trimester of pregnancy. In 1990, 533 pregnant women, while they were in gestational week 30, were randomized to fish oil supplements providing the mentioned amount of long chain n-3 fatty acids, olive oil supplements, or no supplements; they were asked to take the supplements until delivery. Health outcomes were assessed during pregnancy and delivery. Further, offspring health and development has been examined during the ensuring two decades by making linkages to the rich Danish health and administrative registries, by asking the offspring to complete web-based questionnaires, and by examining the offspring physically.
Interventions
DIETARY_SUPPLEMENTFish oil
4 1-g gelatine capsules per day providing 2,7 grams long chain n-3 fatty acids
DIETARY_SUPPLEMENTOlive oil
4 1-g gelatine capsules with virgin olive oil
Sponsors
National Institutes of Health (NIH)
The Danish Council for Strategic Research
Danish Council for Independent Research
Lundbech Foundation
EU Commision, DG12
Centre for Fetal Programming, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy pregnant women in gestation week 30
Exclusion criteria
* Bleeding episodes during pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gestation length | 1989-1990 (1 year) | We assesed impact of fish oil supplementation in pregnancy on timing of spontaneous delivery |
Countries
Denmark
Outcome results
None listed