Multiple System Atrophy, Parkinson's Disease, Progressive Supranuclear Palsy
Conditions
Keywords
biopsies, enteric nervous system, biomarker
Brief summary
The aim of this project is to develop an original biomarker for Parkinson's disease (PD) and other parkinsonian syndromes (multiple system atrophy and progressive supranuclear palsy) based upon the detection of pathological alpha-synuclein species in routine colonoscopic biopsies.
Interventions
PROCEDUREcolonoscopy or rectosigmoidoscopy
Usual procedure
Sponsors
Nantes University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Patients * Patients aged 50-80 year old, both genders * Parkinson's disease patients * Multiple system atrophy patients * Progressive supranuclear palsy patients * Controls: patient at risk of colic cancer for whom a colonoscopy is required * Patients who signed the informed consent Controls * Patients aged 50 to 80 year-old for whom a rectosigmoidoscopy or a colonoscopy is required for colorectal screening * Patients who signed the informed consent * Health care beneficiary
Exclusion criteria
Patients * Colonic disorder (except non-complicated diverticular disease) * Other neurological disorder than parkinsonism * Patients treated with either platelet antiaggregants, anticoagulants or with a known coagulation disorder * Patients with a cognitive impairment that preclude them from understanding the informed consent * Patients placed under legal guardianship Controls * Neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease or other dementia, amyotrophic lateral sclerosis... * Functional bowel disorder such as irritable bowel syndrome * Patients with a cognitive impairment that preclude them from understanding the informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of alpha-synuclein aggregates in colonic biopsies using immunohistochemistry | 3 months | Colonic biopsies are obtained during the course of colonoscopy or rectosigmoidoscopy. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Presence of alpha-synuclein aggregates in colonic biopsies using 2D electrophoresis | 3 months | Colonic biopsies are obtained during the course of colonoscopy or rectosigmoidoscopy. |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORDERKINDEREN Pascal, Professor
Nantes University Hospital
Outcome results
None listed